|
KMID : 0350519930460031005
|
|
Journal of Catholic Medical College
1993 Volume.46 No. 3 p.1005 ~ p.1014
|
|
|
Effect of Breast Feeding on Changes of Blood Gastrin and Bombesin Immunoreactive Peptide Concentration in Newborn Infants During the First Week of Life
|
|
|
|
|
Abstract
|
|
|
It has been known that breast milk contains significant amount of various hormones or peptides, including gastrin and bombesin immunoreactive peptide, which exert direct or indirect trophic effect on the growth and maturation of gastrointestinal
tract.
The concentration of these hormones in breast milk is different according to the gestational period and postpartum days. The highest concentration of gastrin or bombesin immunoreactive peptide is observed in human breast milk secreted during the
first
week after delivery.
It was confirmed that gastrin and bombesin in breast milk are biologically active in the gastrointestinal tract of suckling newborn in animal studies. Gastrin stimulates growth of the mucosa of stomach and bombesin has trophic effect on the
growth
of
intestine and pancreas and also stimulates gastrin secretion from the antral G cell.
This study was performed to investigate the effect of breast milk feeding on the changes of concentration of blood gastrin and bombesin immunoreactive peptide in full term newborn infants during the first week of life.
The infants were divided into two groups : breast feeding group and bottle feeding group. The breast feeding group consists of twenty newborns who fed breast milk and bottle feeding group consists of twenty newborns who fed artificial formula
during the
study period.
2 ml venous blood was obtained from umbilical vein at birth and peripheral vein of forearm or dorsum of hand on the 4th and 7th day after birth and all blood sample was collected between 8 and 12 A.M. before feeding. We analysed blood gastrin and
bombesin immunoreactive peptide level by radioimmunoassay with double-antibody immunoprecipitation method.
@ES The results were as follows :
@EN 1. The mean blood gastrin and bombesin immunoreactive peptide concentrations were not significantly different between breast feeding group and bottle feeding group at birth.
2. The mean blood gastrin concentration was markedly increased on day 4 and day 7, showign postnatal surge in breastfeeding group, however, it was not increased in bottle beeding group. The mean blood gastrin concentration of breast feeding
group
was
significantly higher than that of bottle feeding group on day 4 and day 7.
3. The mean blood concentration of bombesin immuoreactive peptide was increased on day 4 and decreased on day 7 in breast feeding group.
4. Sharp increase of blood gastrin and bombesin imunoreactive peptide level was observed on day 4 in breast feeding group, but there was no significant correlation between blood gastrin and bombesin immunoreactive peptide concentration. After
the
day
4, blood gastrin level was further increased in spite of decreasing blood bombesin immunoreactive peptide level in breast feeding group.
5. There was no significant postnatal increase in blood gastrin level and no correlation was found between blood gastrin and bombesin immunoreactive peptide level in bottle feeding group.
In comclusion, our data suggested that breast feeding I newborns before 7 days of age could induce the postnatal surge of blood gastrin and bombesin immunoreactive peptide level, and therefore we could expect positive effectson the growth and
development of gastrointestinal tract of newborn through breast feeding.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|
|